A deranged DNA damage response as a result of the aberration of ataxia telangiectasia-related (ATR) kinases can lead to significant genomic instability and may contribute to chemoresistance of ENKTL. Deregulation of apoptosis through p53 mutations and upregulation of the anti-apoptotic protein, survivin, may provide a further growth advantage to this tumor. Promoter hypermethylation has been shown to result in the downregulation of other tumor suppressor genes in ENKTL, which may be potentially targeted through hypomethylating agents. The best-studied examples include PR domain zinc finger protein 1(PRDM1), protein tyrosine phosphatase kappa (PTPRK), and FOXO3. Loss of key tumor suppressor genes located on chromosome 6q21 also plays an important role. The discovery of the non-canonical function of EZH2 as a pro-proliferative transcriptional co-activator has shed further light on the pathogenesis of ENKTL. Deregulated pro-proliferative signaling pathways, such as the Janus-associated kinase/signal transducer and activator of transcription (JAK/STAT), platelet-derived growth factor (PDGF), Aurora kinase, MYC, and NF-κB, have been identified as potential therapeutic targets. Novel insights gleaned from high-throughput molecular and genomic profiling studies in recent years have contributed significantly to the understanding of the molecular biology of ENKTL, which exemplifies many of the hallmarks of cancer. There is hence an urgent need for effective targeted therapy, especially for patients with relapsed or refractory disease. Although l-asparaginase-based chemotherapy has resulted in improved response rates, relapse occurs in up to 50% of patients with disseminated disease. Extranodal NK/T cell lymphoma, nasal type (ENKTL) is an aggressive malignancy with a dismal prognosis.
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To store the tripod or travel with it, the legs fold in the reverse to a length of 16.9" and fit into the included carry bag. The head also has a quick release system, which is supplied with a dedicated 200PL PRO plate. The 496 Center Ball Head, which has a load capacity of 22.1 lb, has two independent knobs for the ball movement and for panning, and the main locking knob includes an adjustable tension control on the side of the knob. At the same time, the built-in 90° column mechanism allows you to pull the center column out and slide it back in on its side, letting you shoot right over your subject. The ergonomic leg-angle button disengages the legs, so you can splay the legs at different heights, and you can completely splay the legs out to a minimum height of 3.5" for low-angle or macro photography. It has an average of 4.8 stars from over 800 reviews at B&H Photo.The 3.9 lb Befree GT XPRO Carbon Fiber Travel Tripod with 496 Center Ball Head from Manfrotto is a 4-section support with the twist M-Lock leg system that quickly unlocks with a 90° turn, enabling you to extend the legs along with the rapid center column to a maximum height of 64.6". It’s pricey, though, and uses an unusual head design that can be confusing. If you’re looking for something that folds down even smaller, the Peak Design Carbon Fiber Travel Tripod is as light as the Befree and can carry as big a load. If you’re looking for a travel tripod that packs down really small or don’t mind the extra weight of aluminum, then consider looking at these alternatives. There are a lot of lightweight tripods out there, and often it just comes down to finding the right one for you and your unique needs. I don’t really travel for work anymore - who does right now? - but the Manfrotto carbon fiber Befree tripod is still strapped to my camera backpack, ready to go at a moment’s notice. 4 x payments of R 5 432.50 with ADD TO CART. But Manfrotto’s proprietary M-locks do the job and are fast enough to use, even if they aren’t as speedy as snap locks. Manfrotto Befree GT XPRO Carbon Fiber Travel Tripod with 496 Center Ball Head. Generally, I prefer snap locks to twist locks to extend and contract tripod legs - on earlier tripods I had, the twist locks always managed to loosen up exactly as I was about to take a perfect shot, and they were close to impossible to tighten up enough in cold climates or when it was raining. Each of the legs is separately adjustable, allowing me to use it in pretty much any kind of terrain and at most practical angles. It’s maneuverable and stays where it’s supposed to. The ball head is easy to use and fairly universal to standard camera mounts. It’s also sleekly designed, without unnecessary doodads that can catch on straps, get stuck in foliage or gather dirt or sand. I can’t fit it inside my camera backpack, but I can easily strap or bungee it to the outside, and I have never minded its weight even on the longest, hottest shoots. The carbon fiber Befree itself weighs about 2.7 pounds, noticeably less than aluminum tripods, and slides down to just over 16 inches. And it was never especially unwieldy even when the tripod was fully extended to about 59 inches. That was certainly not light, but it was well under the Befree’s impressive maximum recommended payload of about 18 pounds. Once I switched to the carbon fiber Befree, the tripod stopped vibrating in a fraction of the time and I could get my work done that much more quickly - no small thing when I still had 1,400 shots to get through and 800 more acres to see before moving onto the next site.Īs for a tripod’s weight capacity, when I was outside Lincoln, Nebraska, shooting the 2017 North American solar eclipse, I mounted it with my Canon 5D Mark III, a 70-200 mm telephoto lens, 2x extender and solar filter, about 6.5 pounds in all. With the aluminum tripods I originally started off with, I’d have to count down the seconds after each slight breeze before the metal stopped thrumming and I could safely shoot. I often had to shoot 360-degree panoramas with an 8 mm fisheye lens that had to remain perfectly still for shots in all four directions lest it misalign and require a total reshoot of every shot in the series. Star commentators - For the first time in the FIFA series, FIFA Online 4 is fully voiced by popular English commentators.Physical servers located in Turkey provide a seamless and comfortable experience for the maximum number of players. Special for Turkey - Specially adapted for English players and fully translated into English.Choose your favorite players and turn them into real football stars. Improve your players - Improve the characteristics of your players with the special character development system.Authentic football atmosphere on your computer - Write your own football story! More than 17,000 historical and active stars, more than 600 teams and more than 30 football leagues give you the most realistic experience.You can try different strategies and make team customizations in the coach mode. You can participate in one-on-one matches with your team, league matches and private matches that you can play with your friends. In FIFA Online, which offers an enjoyable experience to players from all walks of life with its careful optimization, advanced controls and customized servers, you can choose your squad among more than 600 teams and more than 17,000 licensed players in more than 30 leagues, including the English Super League and UEFA Champions League you can create. Register now for free football fun and receive exclusive launch rewards! Download FIFA Online 4ĮA Sports FIFA Online 4 is a free football game fully localized into English and developed specifically for PC, featuring all of the essential features of the series and also advanced online and social functionality. If you want, you can buy various items in the game and use them to create your own team. FIFA Online 4 is completely free to play. FIFA Online 4 is the special version for you to play the best football game FIFA series on PC and mobile for free and in English on your computer. 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You can even stop by our Discord server (Link Below) to discuss various suggestions and topics on the game. Significantly cheaper then railway transportation, the Bus system decreases street traffic by offering an alternate option for citizens to commute. If you appreciate a company that focuses on quality, Eden Brothers sells seeds that are 100 percent pure, with no additives and fillers, and germination rates exceeding government standards. Cool TheoTown Seeds Seeds are a special type of generating your city/town at its finest. Manage and customize your transportation vehicles! Pick your aircraft livery, establish your bus routes, build your rail network! Tackle emergency events□, such as natural disasters, disease, crime, and fire. It was constructed as a symbol of the fight for Indonesian independence. Choose how your citizens will move around! Train stations□, airports✈, bus depots□. 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When they eventually did manage to overthrow their father, the three brothers drew straws to see how the world would be divided and who would rule which domain. There are some versions of the story where Poseidon was also given away by his mother same way Zeus was, but these are much harder to come by. But the poets that followed seemed to agree that this association to the sea only came after his father was defeated.Īs the years passed and many different versions of the Greek religion came and went, Poseidon became one of the original six Olympians-the children of Cronus and Rhea, whom all except Zeus were swallowed at Birth by their father. It’s hard to say with any real certainty if the Mycenaeans ever saw Poseidon as the god of the sea because we just don’t know enough about the culture nor the people. But in the absence of his brothers, Poseidon was pretty much the three-in-one Swiss Army knife deity. This in itself is quite interesting because that is a role, we would more commonly associate with his other brother, Hades. The Mycenaeans still saw Poseidon as the god of earthquakes, but he was mostly associated with the underworld and its many rivers. This whole transformation into an animal to have intercourse with someone is something that we see numerous times throughout Greek mythology. One of Poseidon’s earliest stories involves him transforming into a horse to mate with Demeter, who had previously transformed herself into a mare. But most of this can be attributed to the fact that Zeus is a deity that doesn’t appear until much later. Even Persephone was considered the daughter of Demeter and Poseidon, as opposed to Zeus. The role that we now associate with Zeus originally belonged to him. To the Mycenaeans, Poseidon was pretty much the figurehead of their religion. Origin of Poseidonīefore we begin, we have to put aside any Greek pantheon image that we think we have, because the Mycenaean Pantheon is pretty much the foundation that all others were built from. Essentially, the mother of all Greek myths. With an article of this magnitude, we should probably start at the very beginning with the Mycenaean religion. He was the Greek god of the Sea, the god of drought, floods, earthquakes, and horses-his Roman counterpart was NEPTUNE.īut most importantly, one of the Olympians that I still haven’t covered for some reason, and I know some of you have been asking for a while now. Poseidon in Greek Mythology was the son of CRONUS and RHEA. Zeus Greek God Who is Poseidon in Greek Mythology? This can save you HOURS in the right situation.Īnother awesome online web application for editing sound. You can apply compression, reverb, EQ or any effect to a number of audio files at once. My absolute favourite feature of this software is the batch processing (which I discussed in the introduction). It doesn’t support multi-tracking so you can only edit stereo or mono audio files. So is audio scrubbing, which can be very handy. Reverse reverb: here’s how to create this cool trick. There are also some great analysis tools for more advanced users. There are lots of bundled effects including noise removal, compression and reverb. The interface may not be as sleek as some of the editors listed here, but it makes up for this in features. This is ideal if you are recording or editing on the fly and don’t want to install large programme on to your laptop.Ī slightly older DAW, but still highly useful. Click here to see how to master a song at home. There are several out there for music composition already and now more audio editors are appearing too. You can load and save in the cloud, apply live effects and share to social media or via URL (take a listen to a song I applied some compression and a high-pass filter to here: )īrowser based DAWs could be the future of audio editing. It doesn’t support multi-tracking but you can copy, paste, cut, clear and crop your audio. The interface is clean and user friendly and the learning curve is pretty much non-existent. Released in January 2015, I only discovered this a few months ago. This is a member of the new wave of online audio editors that run in your internet browser. It’s also relatively simple in terms of features compared to Audacity, although they aren’t trying to compete on that front. More on recording voice and mixing vocals here.īut for editing stereo music files, or mono audio files (such as a voice recording) this is awesome. You can’t have a multi-track session and record several instruments in your home studio and mix them. One downside of this software is that it only supports single stereo/ mono files. There are lots of useful tools (such as a spectogram) for the more advanced user. It’s easy to record audio straight in to the software as well. The editor has VST support so you can use your own plugins. But in ocenaudio you can play with the parameters of the effect and hear the changes instantly. This is a huge benefit as most free editors are destructive (they record effects straight to the audio) so you have to rely on a ‘preview’ button. It’s bundled with loads of effects (including compression, EQ and reverb) that you can apply and tweak in real-time. It’s so easy to use! It’s fast and it’s lightweight compared to Audacity. This new simple audio editor has a clean and colourful user interface. This is an awesome starting point for anyone wanting a free editor. It looks a bit ancient, but it gets the job done. The user interface is not particularly appealing, and there a lot of features that you’ll rarely use that clutter the tool bar. You might also like our post on how to eq vocals. Recording is easy too. Tip: Reset all the gain sliders if you want to do a gain staging/ track balancing. Deleting and muting sections of audio is also a breeze. Volume automation is easy using the envelope. It’s by far the most popular free audio editing software. There are a range of effects and plugins, and it’s easy to use once you get used to it. You can multi track to an extent (have more than just one stereo track e.g. This is the godfather of free audio editing software. Which Audio Editor Do I Use? Audacity (Windows, Mac, Linux) Save Your Attacks That Target All Enemies For Your Final Battle From the very start of the game. So if your Chewbacca needs a new Mk 1 BlasTech Weapon Mod, chances are the game will point you towards the right Light Battle you’ll need to beat. Here are the top 10 tips/tricks/cheats you need to know for Star Wars: Galaxy of Heroes. Accomplishing this helps you figure out which missions you’ll need to complete in order to get the items you need. Simply check out one of your characters, tap onto any one of their inventory slots and click on the Find option. The self-assembling crystals of the Outworld make a very good staff. If you’re running low on one particular item or you’re searching for your 1st piece of something entirely new, there’s an easy way to locate what you need. Date Received: (12:27:55) Dedication:, ,. There’s a ton of items that needs collecting in the game.It’s Pretty Easy to Find The Items You Need Do all of this and you’ll be able to conquer anyone you face in Challenge Mode.ĥ. And of course, keep at least one Healer on deck. Characters with debuff abilities are your best bet for Challenge Mode battles. Topic Fleet Command - Win legion war: General shards started Aug 30, 2021. For skirmishes such as these, you’ll have to equip party members that can use abilities that brings down the offensive capabilities of your enemies. Share tips or discuss about Fleet Command - Win legion war Cheats. Some of the boss characters that you’ll face can kill your party with little to no effort. When you eventually unlock Challenge Mode, be ready to take on some enemies that are much MUCH stronger than the ones you’ve faced before.You should plan out all your attacks based on this battle tactic. data:image/png base64,iVBORw0KGgoAAAANSUhEUgAAAKAAAAB4CAYAAAB1ovlvAAAAAXNSR0IArs4c6QAAHCNJREFUeF7tnQd0VFXXht+ZSQ8lIYFEqmBoiiAiTYpSBGkWQJrto9mooYOACooURanSBQQ. In some cases at the start of a battle, try to eliminate the strongest enemy who already has their blue meter filled. Aim all of your attacks at that target so you can have a chance to down them before they make a move. So during battles, keep a close eye on the enemy who’s blue bar is close to filling up all the way. So that means you should always keep an eye on your foes’ blue meters. Aetherblade's Downfall Ascalon's Searing Final Sorrow Malchor's Demise Marionette's Defeat. Twilight I: The Experimental Nightsword collection. See that blue meter that rests right underneath everyone’s green health bar? Once it fills up completely, that character will be able to actively participate in battle. Interact with the Plaque that tells the story about the end of the Ascalonian human civilization at the Shards of War in the Plains of Ashford. 5R Ultra-light Rigid Wheelchair: This model has an open frame design and swept axle plate, and it weighs just 21.5 pounds.Its real axles can be adjusted both horizontally and vertically. LXI Ultra-light Wheelchair: With swing in and out footrests, this foldable wheelchair gives the user different options.Quickie 2 Ultra-light: This foldable unit comes with black anodized chair parts, multiple wheel and caster combinations, and customizable armrests.There are some titanium options that provide added strength. The sport wheelchairs include those made specifically for the basketball or tennis court. If you're looking for a Quickie wheelchair that is smaller and mobile, you can consider their sport and ultra-light models. Examples of models that have these different systems include: Rear-wheel drive models may offer a smoother ride, and you may prefer the stability they offer. Typically, mid-wheel drive wheelchairs are more maneuverable, so they may be more ideal in smaller, indoor spaces. The company's wheelchairs come in either rear- or mid-wheel drive. This can come in handy if you have limited arm strength and/or must travel long distances. There are numerous Quickie wheelchairs that rely on a motor instead of manual force to propel itself forward. What are the choices for power wheelchairs? You can find a variety of new and used options on eBay. The company makes many types of wheelchairs to accommodate those in different situations. "During its development phase, we had an audacious goal with the Magic 360 to create the world’s narrowest true all-terrain powerchair, making you look good and feel good, going indoors and outdoors.A Quickie wheelchair can be just what you need if you require some assistance to maintain your lifestyle. Jill McKechnie, Magic Mobility's General Manager, commented on the award "It’s brilliant to have the Magic 360 recognised as a leader in its field and a top choice for UK retailers - Magic Mobility have worked tirelessly over the past 28 years to give our users the best opportunity to embrace a world that’s not flat." Its unique three set of wheels options allows customers to effectively have three powerchairs in one, just by changing the wheels.” "The Magic 360 is a mid-wheel drive powerchair like none other on the market. We’re delighted to announce that the Magic 360 has been named one of the Retailers’ Choice Products Of The Year in the annual feature from THIIS Magazine.ĭarren Macey, Business Development Manager at Lifestyle & Mobility said, “We always seek products that are both innovative and have the ability to enhance customers lives." QUICKIE Nitrum Active Wheelchair | Sunrise Medical Learn about the Nitrum, create your own design and try out the AR application at #QuickieNitrum #ManualWheelchair #RedDotAwards #ProductDesign #ImprovingPeoplesLives Not only pioneering in product designs, Sunrise Medical has also featured the industry leading customer experience tools with the launch of QUICKIE Nitrum, including the highly innovative 3D visualizer and cool illustration tool with the cutting edge Augmented Reality technology. We make sure that we consider all the finest details in our designs and innovations, and we are pleased it won over the jurors to receive a distinction in the Red Dot Award.” “The valuable feedback from our customers have significantly influenced and advanced our development of Nitrum. The team worked relentlessly to engineer an ultra lightweight wheelchair that provides a smooth ride for users of wheelchairs,” said Thomas Babacan, Sunrise Medical’s group CEO. “We are thrilled that Nitrum has been recognized by Red Dot Design Award for its superior design. In less than a month after launch, Nitrum was awarded "Retailer's Choice of the Year 2020" by one of the most influential European trade magazines "THIIS" in the UK. The ultra lightweight wheelchair won the Mobility Product Award 2021 in the Manual Ultra Lightweight wheelchair category by Mobility Management in the US. Packed with numerous newly patented features and frame designs, the QUICKIE Nitrum ultra-light wheelchair has become a global phenomenon and has already won multiple prominent awards since launched in 2020. We are very proud to announce that the QUICKIE Nitrum® has received another prestigious award! This time is the renowned Red Dot Award for Product Design 2022 from Germany, well recognised worldwide which is one of the most sought-after seal of quality for products that feature an outstanding design. 3D VRThe Falconeer in VR expands the boundaries of the Great Ursee offering fully immersive views of the oceanic world. TOMAS SALAThe Falconeer is the sole vision of maverick independent developer, Tomas Sala. SOUNDS OF THE URSEEImmerse yourself in the world of The Falconeer with an award-winning soundtrack. FULLY VOICEDAn incredible voice cast brings to life the world within the Falconeer. UPGRADE YOUR MOUNTSurvive and earn splinters to improve your gear and mount. MULTIPLE CAMPAIGNSExperience life as a Falconeer from many different perspectives. RIVAL FACTIONSJoin and support your faction, taking on missions that may change the fate of your comrades as well as your own. FRENETIC AERIAL COMBATSoar above the clouds and engage in spectacular aerial dogfights. EXPLORE AN INCREDIBLE UNIVERSEDiscover a vast oceanic world filled with lost myths and breathtaking landscapes. TAKE TO THE SKIESExperience the free-flying escapism of flying a giant warbird across a stunning open world. Dive through the deep ocean depths, soar above the clouds to do battle with giant crab cities or engage in furious dogfights against the mysterious Mancer Order that controls and regulates technology. In the game players will create their own fortified settlements within the haunting landscapes of the Ursee, the world of The Falconeer. Progress through perilous missions and side quests, wielding your lightning caster to protect ships against pirates, kraken and other threats. Throughout multiple campaigns, you will experience life from many different perspectives and loyalties as you embark on a journey of discovery, and solve the mystery of the Ursee, its people and history. Combining classic dog fighting mechanics and acrobatic twists and turns with an awe-inspiring open environment and bestiary of fantastic enemies in land, sea, and air, The Falconeer is an. Let your creativity run wild as you become the creator of your own Bulwark. In this sense the game is one of experimental gameplay and controls, supported by a world and settlement that comes alive before your eyes. The Falconeer, World Map has a very paper-like feel to it GAMEPLAY The Falconeer is a breath of fresh air, pun intended, in the era of shooters and battle royales, as it forces players to think in terms of vectors, speed, and altitude, rather than headshots, twitch reflexes, and so on. You take on the role of Falconeer, a powerful airborne warrior traversing a vast oceanic world torn apart by generations of poisonous decisions and dissent. This requires a novel approach to building, something that isnt about clicking over a screen but focusing on the world itself. Soar through the skies aboard a majestic warbird, explore a stunning oceanic world and engage in epic aerial dogfights, in this BAFTA nominated air combat game from solo developer, Tomas Sala. |